Synthesis of a Novel Products of 1, 3, 4 - Oxdiazole Containing Thiozolidine -4-one Derivatives

Rama Krishna Vellalacheruvu, R. Sai Leela, Dr L. K. Ravindranath

Abstract


8-(benzyloxy)quinoline-5-carbaldehyde(1)was converted into 2-(8-(benzyloxy)quinolin-5-yl)-3-(4-(trifluoromethyl)phenyl)thiazolidin-4-one (3) by using  conventional   method of  Schiff’s base and cyclised using mercapto acetic acid and anhydrous ZnCl2 in 1,4 Diaoxane. These intermediate (3) was converted to 2-((5-(4-oxo-3-(4-(trifluoromethyl) phenyl) thiazolidin-2-yl) quinolin-8-yl) oxy) acetohydrazide (6) by using hydrogenolysis and treated with Ethyl bromo acetate and hydrazine hydrate. The intermediate (6) was converted into thiozolidine attached 1,3,4 oxa diazole derivatives  (7a-h) was synthesized  using benzaldehyde analogs and I2 / K2CO3 .and  scaffolds were thoroughly characterized. The thiozoldine attached benzimidazole and benzthiozole, benzoxazole derivatives were synthesized using PPA and characterized.


Keywords


1, 3, 4; Oxadiazol; Quinolines Thiozolidine-4- One Nucleus; Combi- Flash Chromatography.

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References


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