Impact of general anesthesia on the activity of lipids peroxidase oxidation during cardiac surgery for elderly patients

Abstract

This paper examines lipid peroxidation (LPO) dynamics and antioxidant system(AOS) values in 43 patients (aged 69,11 ± 1,99, with the weight of 83.7 ± 1.15 kg) during coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB).

The use of propofol resulted in the increase of diene conjugates number (DC) by 17.1 ± 0,40% on the background of higher values of malondialdehyde (MDA) 18.4 ± 1,08% relative to previous values. While with the use of sevoflurane an increase of DC level by 30.1 ± 1,88% on the background of MDA decrease by 19,03 ± 1,01% was noticed.

By the end of the operation propofol group showed a decrease in DC values by 20,14 ± 1,93% compared to the previous values and MDA level decrease by 42.8 ± 1,99% on the background of a questionable increase of ceruloplasmin level (CP). While with the use of sevoflurane we could observe DC decrease by 39.1 ± 1,84% compared to the previous values on the background of CP level increase by 28.8 ± 1,82%.

Thus, the anesthetics under study showed differently directed effect on prooxidant and antioxidant systems of the body and a more distinctive effect on the increase of ceruloplasmin antioxidant level was determined with the use of sevoflurane.